2000;23(5):272-274. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Extracts were added in the amount of 2.0 g/100 g of meat batter. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. 1995;15(8):465-467. Pharmacol Biochem Behav 2009;92(4):642-648. Biological properties of baicalein in cardiovascular system. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Diabetes medicines: These These include the Chinese Skullcap, Huang Qin, Scutellaria baicalensis (the scientific name), and the Hooded Willow Herb. Biol Pharm Bull 2004;27(10):1580-1583. Afr J Tradit.Complement Altern Med 2010;7(4):339-349. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. It is not an approved drug. Chen C, Mireles RJ, Campbell SD, et al. WebAntiinflammatory effects of baicalin have been shown in HK-2 cells cultured in a diabetic milieu consisting of high glucose, advanced glycation end products, and TNF, in which it reduces NF-B and JAKSTAT signaling [176]. 5-17-2011;135(2):359-368. WebBaicalin is a great herbal supplement for health benefits. Zhang H, Huang J. View abstract. Life Sci 10-27-2000;67(23):2889-2896. 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In human colon cancer cells, S. barbata induces apoptosis and inhibits cell proliferation and angiogenesis via Akt and p53 modulation, Bax/Bcl-2 upregulation, decreased cyclin D1/CDK4 expression, G1/S cell cycle arrest, VEGF-A inhibition, and increased p21 expression(19)(20)(26)(27). Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. Ding, X. F., Gao, H. N., Guo, X. H., Wang, Z. Some medications are moved in and out of cells by pumps. Cancer Lett. View abstract. Toxicology 3-4-2009;257(1-2):80-85. 1997;11(3):125-131. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. View abstract. J Ethnopharmacol. Burnett BP, Jia Q, Zhao Y, Levy RM. Afr J Tradit Complement Altern Med. Taking Baikal skullcap with medications used to treat high blood pressure might cause blood pressure levels to go to low. View abstract. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. View abstract. 1998;61(2):54-56. Wang, Z. Liao JF, Wang HH, Chen MC, et al. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Am J Chin Med 2009;37(3):621-623. Baikal skullcap might lower blood pressure. 4-12-2011;134(3):884-891. View abstract. Integr.Cancer Ther. Studies indicate that aqueous extracts suppressed the growth of lymphoma and myeloma cells. Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. Jin BR, Chung KS, Kim HJ, An HJ. Luna-Bastante L, Gatica-Ortega ME, Pastor-Nieto MA, et al. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. 2009;48(12):1159-1169. 2004;91(1):65-68. [Analysis of main flavonoids contents of Scutellaria baicalensis]. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. Phytother.Res 2007;21(9):900-903. Monitor your blood sugar closely. View abstract. J Ethnopharmacol. The pharmacology of Chinese herbs. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. Some medications are changed and broken down by the liver. This could change the effects and side effects of these medications. It is often used in combination with other herbs. Biol Pharm Bull 2003;26(1):79-83. Luo, X., Zhou, X., Su, P., and Zhu, W. [Effects of Scutellaria baicalensis stem-leaf total flavonoid on proliferation of vassel smooth muscle cells stimulated by high triglyceride blood serum]. View abstract. 2008;6(1):103-8. View abstract. Int J Cancer 9-10-2003;106(4):559-565. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Get medical attention if irritation develops and persists. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. View abstract. Seattle, WA: Eastland Press 1996:107-8. Do you know this herb by any other name ? J Med Chem 10-21-2004;47(22):5555-5566. View abstract. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel Baicalin is believed to interfere with hormonal reactions and release of histamines and bile in the body; it stimulates gallbladder activity, inhibits inflammation, as well as suppresses the activity of leukaemia-derived T-cells and replication of viruses and bacteria. Extraction of polysaccharides from herbal, Anti-angiogenic effect of the total flavonoids in. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Planta Med 2001;67(5):396-399. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Contraindications Adverse Reactions References Back to top # A B View abstract. View abstract. Baicalein: an in vitro antigenotoxic compound from Scutellaria baicalensis. Kaplya, O. Arch Dis Child 1993;68:468-71. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. View abstract. Z., Yang, L. H., Guan, Y., and Shi, J. S. [Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy]. Afr J Tradit Complement Altern Med. ]. Chalasani N, Vuppalanchi R, Navarro V, et al. These medications include atorvastatin (Lipitor), cerivastatin (Baycol), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and simvastatin (Zocor). Ceska.Slov.Farm. Puri BK, White N, Monro JA. 2007;56(6):280-283. Cancer Res 7-15-2003;63(14):4037-4043. reduce wrinkles, smooth skin) but without the side effects (though it seems now that the INCI name of Lanablue was View abstract. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. B., and Bae, K. H. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. Preclinical studies of S. barbata have focused mostly on colon, lung, and liver cancer models. Planta Med 2000;66:91-3. Diabetes medications are also used to lower blood sugar. Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Scutellaria Macrantha , Scutellaria Baicalensis, Family: Lamiaceae. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. View abstract. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Some constituents may also have neuroprotective (4) (5) , anticonvulsant (6) , and anti-inflammatory (17) effects. Some medications are moved by pumps into cells. Immunopharmacology 2000;49:295-306. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. View abstract. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Li-Weber, M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Lee, C. Y., Wang, J. Y., Chen, T. C., Jiang, J. K., Peng, C. H., Kuo, C. D., Chang, W. C., Chiu, J. H., and Wu, C. W. Effects of S/B remedy containing Scutellaria baicalensis and Bupleurum scorzonerifolfium on hepatic interleukin-6 related signal transducer and activator of transcription 3 activation in mice through cell-cell interaction. September 2012. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. A combination of Scutellaria baicalensis and Acacia catechu for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee. View abstract. Larger studies in humans that test safety and effectiveness are needed to determine under what circumstances S. baicalensis may be beneficial. View abstract. View abstract. View abstract. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. View abstract. 2010;16(2):32-40. WebMD does not provide medical advice, diagnosis or treatment. View abstract. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Clin Transl Sci 2021;14(5):2017-2024. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Biull.Eksp.Biol Med 1999;128(9):327-329. View abstract. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. View abstract. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. J Ethnopharmacol 2005;98:295-300. View abstract. J Nat Prod 1997;60(6):598-601. View abstract. Morgan SL, Baggott JE, Moreland L, et al. 2006;5(1):9-29. View abstract. Li WJ, Bao J, Zheng DC, et al. It is also used for gastrointestinal (GI) infections, as well as liver problems including viral hepatitis and jaundice. Mol Urol. View abstract. Bull Exp Biol Med 2002;134(1):47-49. Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. Phytother Res 2000;14:210-2. View abstract. Elevated high-sensitivity C-reactive protein and high triglycerides were possibly related to ingestion of baicalein tablets in healthy subjects and should be monitored in future studies(25). B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? View abstract. Yim, J. S., Kim, Y. S., Moon, S. K., Cho, K. H., Bae, H. S., Kim, J. J., Park, E. K., and Kim, D. H. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. 2019;2019:3239649. Lai, M. Y., Hsiu, S. L., Chen, C. C., Hou, Y. C., and Chao, P. D. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Nat Prod 1998;61:1413-5. Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics. View abstract. A preliminary study of S. baicalensis along with metformin appeared to improved glucose tolerance, inflammation, and gut microbiota in patients with type 2 diabetes(23). In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. Ann Intern Med 2012;156:857-60. Planta Med 1998;64:571-2. View abstract. View abstract. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. View abstract. View abstract. Your Query - This is a community service. Next to red peppers, you can get the most vitamin C from ________________. View abstract. 2011;39(1):217-224. J Chromatogr.A 3-19-2010;1217(12):1875-1881. Evid Based Complement Alternat Med. View abstract. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. This herb is often used alone, whereas many times, it is used with other herbs in combination. Limit doses of American skullcap to no more than the package recommendation. Lam, T. L., Lam, M. L., Au, T. K., Ip, D. T., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. 7-28-2004;211(1):39-46. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects(9). View abstract. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Phytomedicine. 2020 Apr;82(4):253-254. 2019;235:481-488. Contact Dermatitis. Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Zhou, X., Zhang, Q., Liang, H., Jiang, Y., Wang, X., Wang, B., and Zhao, Y. Chan, E., Liu, X. X., Guo, D. J., Kwan, Y. W., Leung, G. P., Lee, S. M., and Chan, S. W. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. Br J Pharmacol 2009;157:1410-18. View abstract. Liu, C. Z. and Chen, D. W. [Sanhuang tablets research]. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. Therefore, if you are a diabetic patient, you should stay away from such herbs. Keep in mind that natural products are not always necessarily safe and dosages can be important. Food Chem Toxicol. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Am J Chin Med 2006;34(2):245-261. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. Mol Pharmacol 2001;60(3):507-513. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Levy RM, Saikovsky R, Shmidt E, et al. Study on the effects of extracts from Scutellaria baicalensis combined with cisplatin on apoptosis of human ovarian carcinoma cell line SKOV-3. [Effect of Radix scutellariae on the growth and form of Porphyromanus endodontics in vitro]. View abstract. 2-1-2010;84(2):137-144. Scutellaria baicalensis Georgi extracts inhibit RANKL-induced osteoclast differentiation. Wu, J. View abstract. View abstract. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Cells in the dietary management of knee osteoarthritis a diabetic patient, you can get the vitamin! Nat Prod 1997 ; 60 ( 6 ):598-601 Limbrel ), a medical food, in the management. C from ________________ level of viral entry 47 ( 22 ):5555-5566 Med 2009 ; 92 4..., Wang, scutellaria baicalensis root extract side effects mechanism of Scutellaria baicalensis and Acacia catechu acts as a dual of. G. flavones from root of Scutellaria baicalensis ] clin Transl Sci 2021 ; 14 5! 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